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KMID : 1022820160070020029
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Journal of Multiple Sclerosis and Neuroimmunology
2016 Volume.7 No. 2 p.29 ~ p.36
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Clinical Practice Guideline of Clinically Isolated Syndrome: Part I. Evaluation and Diagnosis
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Kim Su-Hyun
Park Min-Su
Kang Sa-Yoon
Kim Nam-Hee
Kim Sun-Young
Kim Sung-Min
Kim Jee-Young
Nam Tai-Seung
Min Ju-Hong
Shin Ha-Young
Oh Jee-Young
Cho Jeong-Hee
Cho Joong-Yang
Huh Jung-Won
Kim Woo-Jun
Kwon O-Hyun
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Abstract
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Clinically isolated syndrome (CIS) is the typical first clinical episode that is highly suggestive of multiple sclerosis (MS). Without diagnostic marker, diagnosing CIS is exactly alike diagnosing MS with even less evidences and requires careful and integrative interpretation of clinical, radiological and immunological findings. In the aspect of management, numerous clinical trials and cohort studies strongly support prompt start of disease modifying therapies even in the stage of CIS to prevent disability accumulation with disease activity. This guideline covers sequential stages of clinical practice - encounter, assessment, diagnosis, and management - and addresses their principal evidences to help clinicians make correct diagnosis and proper management. Though it cannot be emphasized too much to consider every possible differential diagnosis other than MS thoroughly when we encounter patients with CIS, the details regarding differential diagnosis are out of the scope of this guideline. The guideline would be regularly updated and revised every a few years to serve its role.
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KEYWORD
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Clinically isolated syndrome, Evaluation, Diagnosis, Guideline
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